The African Swine Fever Virus IAP Homolog Is a Late Structural Polypeptide

• Published in: Virology (New York, N.Y.) N.Y.), 1995-12, Vol.214 (2), p.670-674
• Main Authors: CHACÓN, MATILDE R., ALMAZÁN, FERNANDO, NOGAL, MARIA L., VIÑUELA, ELADIO, RODRÍGUEZ, JOSE F.
• Format: Article
• Language: English
• Subjects: African swine fever virus; African Swine Fever Virus - chemistry; African Swine Fever Virus - genetics; Amino Acid Sequence; Animals; ARN; Base Sequence; Cell Line, Transformed; Cercopithecus aethiops; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DNA, Viral; EXPRESION GENICA; EXPRESSION DES GENES; GENE; GENES; Inhibitor of Apoptosis Proteins; LOCALISATION DE GENE; LOCALIZACION DE GENES; Molecular Sequence Data; PEPTIDE; PEPTIDOS; PROTEINAS; PROTEINE; RNA, Viral - metabolism; Sequence Homology, Amino Acid; Vero Cells; Viral Proteins - chemistry; Viral Structural Proteins - chemistry; Viral Structural Proteins - genetics; VIRUS DE LA PESTE PORCINA AFRICANA; VIRUS DE LOS ANIMALES; VIRUS DES ANIMAUX; VIRUS PESTE PORCINE AFRICAINE
• ISSN: 0042-6822; 1096-0341
• DOI: 10.1006/viro.1995.0083

The analysis of the complete nucleotide sequence of the African swine fever virus genome has revealed the existence of a number of genes potentially capable of modifying the host's response to the virus infection. In this report, we describe the results of the characterization of the A224L gene that encodes a novel member of the family of apoptosis inhibitors known as IAP proteins. A224L is expressed during the late phase of the infectious cycle, and its polypeptide product is assembled into virus particles.