Nuclear lipid metabolism in NEST: Nuclear Envelope Signal Transduction

There is increasing evidence that nuclear lipid metabolism in NEST is an important new component in signal transducing networks and as a result, this metabolism is beginning to attract more attention. While agonist-induced nuclear lipid metabolism adds further complexity to the ever increasing array...

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Bibliographic Details
Published in:The Journal of membrane biology 1994-10, Vol.142 (1), p.1-7
Main Authors: Raben, D M, Jarpe, M B, Leach, K L
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Arachidonic Acid - metabolism
Cell Line
Diglycerides - metabolism
Enzyme Activation
Hydrolysis
Membrane Lipids - metabolism
Mice
Models, Biological
Nuclear Envelope - physiology
Phosphatidylinositol Diacylglycerol-Lyase
Phospholipids - metabolism
Phosphoric Diester Hydrolases - metabolism
Protein Kinase C - metabolism
Signal Transduction - physiology
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Summary:There is increasing evidence that nuclear lipid metabolism in NEST is an important new component in signal transducing networks and as a result, this metabolism is beginning to attract more attention. While agonist-induced nuclear lipid metabolism adds further complexity to the ever increasing array of signal transduction components, it also provides further avenues by which nuclear activities may be regulated. Identification of the coupling mechanisms, regulation, and physiological roles of nuclear lipid metabolism represents a new and exciting area of research which will have a broad impact in our understanding of signal transduction pathways.
ISSN:0022-2631
1432-1424
DOI:10.1007/BF00233378