Deficiency of a neuronal growth-sustaining factor in fibroblasts of patients with Alzheimer's disease

A previous report has shown a deficiency of a cholinergic differentiating factor in spent culture media in which Alzheimer's disease (AD) patient fibroblasts were grown (Kessler, 1987). We used a similar approach to investigate whether AD fibroblast-conditioned medium demonstrated central nervo...

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Bibliographic Details
Published in:Journal of the neurological sciences 1995-11, Vol.133 (1), p.24-30
Main Author: Plioplys, Audrius V.
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer's disease
Animals
Biological and medical sciences
Cell Survival - physiology
Culture Media, Conditioned
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Fibroblasts
Fibroblasts - physiology
Growth factor
Humans
Male
Medical sciences
Mice
Nerve Growth Factors - deficiency
Neurology
Neurons - cytology
Tissue culture
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Summary:A previous report has shown a deficiency of a cholinergic differentiating factor in spent culture media in which Alzheimer's disease (AD) patient fibroblasts were grown (Kessler, 1987). We used a similar approach to investigate whether AD fibroblast-conditioned medium demonstrated central nervous system (CNS) neuronal growth sustaining properties. For these investigations we used cultured fetal murine telencephalic vesicle neurons. Control fibroblast-conditioned medium produced statistically significant neuronal survival as compared to AD fibroblast-conditioned medium or to nonconditioned medium. There was no statistically significant difference between AD fibroblast-conditioned medium and nonconditioned medium results. These results suggest that there may be a deficiency in AD of a CNS neuronal growth-sustaining factor.
ISSN:0022-510X
1878-5883
DOI:10.1016/0022-510X(95)00171-W