Susceptibility of HIV to inactivation by disinfectants and ultraviolet light

Assays were developed to assess a variety of conditions and presentations of infectious HIV to potential inactivating sources. A range of commercially available disinfectants with active constituents including glutaraldehyde, chlorine, phenolics, alcohol, iodine and quaternary ammonium compounds was...

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Bibliographic Details
Published in:The Journal of hospital infection 1995-07, Vol.30 (3), p.167-180
Main Authors: Druce, J.D., Jardine, D., Locarnini, S.A., Birch, C.J.
Format: Article
Language:English
Subjects:
AIDS/HIV
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiseptics
Biological and medical sciences
Blood - virology
Cell Line
Culture Media
disinfectants
Disinfectants - pharmacology
Disinfection - methods
HIV
HIV-1 - drug effects
HIV-1 - radiation effects
human immunodeficiency virus
Humans
Medical sciences
Pharmacology. Drug treatments
u.v. light
Ultraviolet Rays
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Summary:Assays were developed to assess a variety of conditions and presentations of infectious HIV to potential inactivating sources. A range of commercially available disinfectants with active constituents including glutaraldehyde, chlorine, phenolics, alcohol, iodine and quaternary ammonium compounds was tested. In addition, u.v. light was investigated as a potential inactivating source. All products were assessed against cell-free HIV in culture medium and cell-associated HIV suspended in medium or whole human blood. All products completely inactivated cell-free HIV following a 1 min exposure. However, cell-associated HIV was more resilient, requiring exposure of 5 min or more for some disinfectants. The effectiveness of the disinfectants was further compromised in the presence of blood.
ISSN:0195-6701
1532-2939
DOI:10.1016/S0195-6701(95)90312-7