Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium

We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely...

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Bibliographic Details
Published in:European heart journal 1994-12, Vol.15 Suppl D (suppl D), p.88-91
Main Authors: Holubarsch, C, Schmidt-Schweda, S, Knorr, A, Duis, J, Pieske, B, Ruf, T, Fasol, R, Hasenfuss, G, Just, H
Format: Article
Language:English
Subjects:
Angiotensin I - physiology
Angiotensin II - physiology
Atrial Function
Culture Techniques
Dose-Response Relationship, Drug
Heart Atria - drug effects
Heart Ventricles - drug effects
Hemodynamics - drug effects
Hemodynamics - physiology
Humans
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Prazosin - pharmacology
Propranolol - pharmacology
Receptors, Angiotensin - drug effects
Receptors, Angiotensin - physiology
Saralasin - pharmacology
Ventricular Function
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Summary:We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/15.suppl_D.88