Loading…
Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium
We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely...
Saved in:
| Published in: | European heart journal 1994-12, Vol.15 Suppl D (suppl D), p.88-91 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c240t-7ac12dd5c5e70cf58e662c0759e674bbe2f39d0348a1576c192070f53e0bbdae3 |
|---|---|
| cites | |
| container_end_page | 91 |
| container_issue | suppl D |
| container_start_page | 88 |
| container_title | European heart journal |
| container_volume | 15 Suppl D |
| creator | Holubarsch, C Schmidt-Schweda, S Knorr, A Duis, J Pieske, B Ruf, T Fasol, R Hasenfuss, G Just, H |
| description | We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype. |
| doi_str_mv | 10.1093/eurheartj/15.suppl_D.88 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77808191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77808191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c240t-7ac12dd5c5e70cf58e662c0759e674bbe2f39d0348a1576c192070f53e0bbdae3</originalsourceid><addsrcrecordid>eNpNkUtLxDAUhYMo4_j4CWJW7jom7eTRpaijguBCBXchTW800qY1D2V-gX_bisPg6nLgfOfAPQidUrKgpK7OIYc30CG9n1O2iHkcO3W1kHIHzSkry6LmS7aL5oTWrOBcvuyjgxjfCSGSUz5DMyFoRUsyR9-r7E1yg9cdju7VO-uM9gbwYLH2r25I4KPzOICBMQ0h4km85V573K8Ho0Prcr_Aj1s04dZZCwGmkIgbSF8AHusU3NSgfYs_wU_C5E6HfxFHaM_qLsLx5h6i59X10-Vtcf9wc3d5cV-YcklSIbShZdsyw0AQY5kEzktDBKuBi2XTQGmruiXVUmrKBDe0LokgllVAmqbVUB2is7_cMQwfGWJSvYsGuk57GHJUQkgiaU0no_gzmjDEGMCqMbheh7WiRP1OoLYTKMrUZgIl5USebCpy00O75TY_r34A86GMmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77808191</pqid></control><display><type>article</type><title>Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium</title><source>Oxford University Press Archive</source><creator>Holubarsch, C ; Schmidt-Schweda, S ; Knorr, A ; Duis, J ; Pieske, B ; Ruf, T ; Fasol, R ; Hasenfuss, G ; Just, H</creator><creatorcontrib>Holubarsch, C ; Schmidt-Schweda, S ; Knorr, A ; Duis, J ; Pieske, B ; Ruf, T ; Fasol, R ; Hasenfuss, G ; Just, H</creatorcontrib><description>We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/15.suppl_D.88</identifier><identifier>PMID: 7713120</identifier><language>eng</language><publisher>England</publisher><subject>Angiotensin I - physiology ; Angiotensin II - physiology ; Atrial Function ; Culture Techniques ; Dose-Response Relationship, Drug ; Heart Atria - drug effects ; Heart Ventricles - drug effects ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Humans ; Myocardial Contraction - drug effects ; Myocardial Contraction - physiology ; Prazosin - pharmacology ; Propranolol - pharmacology ; Receptors, Angiotensin - drug effects ; Receptors, Angiotensin - physiology ; Saralasin - pharmacology ; Ventricular Function</subject><ispartof>European heart journal, 1994-12, Vol.15 Suppl D (suppl D), p.88-91</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c240t-7ac12dd5c5e70cf58e662c0759e674bbe2f39d0348a1576c192070f53e0bbdae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7713120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holubarsch, C</creatorcontrib><creatorcontrib>Schmidt-Schweda, S</creatorcontrib><creatorcontrib>Knorr, A</creatorcontrib><creatorcontrib>Duis, J</creatorcontrib><creatorcontrib>Pieske, B</creatorcontrib><creatorcontrib>Ruf, T</creatorcontrib><creatorcontrib>Fasol, R</creatorcontrib><creatorcontrib>Hasenfuss, G</creatorcontrib><creatorcontrib>Just, H</creatorcontrib><title>Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.</description><subject>Angiotensin I - physiology</subject><subject>Angiotensin II - physiology</subject><subject>Atrial Function</subject><subject>Culture Techniques</subject><subject>Dose-Response Relationship, Drug</subject><subject>Heart Atria - drug effects</subject><subject>Heart Ventricles - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Contraction - physiology</subject><subject>Prazosin - pharmacology</subject><subject>Propranolol - pharmacology</subject><subject>Receptors, Angiotensin - drug effects</subject><subject>Receptors, Angiotensin - physiology</subject><subject>Saralasin - pharmacology</subject><subject>Ventricular Function</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpNkUtLxDAUhYMo4_j4CWJW7jom7eTRpaijguBCBXchTW800qY1D2V-gX_bisPg6nLgfOfAPQidUrKgpK7OIYc30CG9n1O2iHkcO3W1kHIHzSkry6LmS7aL5oTWrOBcvuyjgxjfCSGSUz5DMyFoRUsyR9-r7E1yg9cdju7VO-uM9gbwYLH2r25I4KPzOICBMQ0h4km85V573K8Ho0Prcr_Aj1s04dZZCwGmkIgbSF8AHusU3NSgfYs_wU_C5E6HfxFHaM_qLsLx5h6i59X10-Vtcf9wc3d5cV-YcklSIbShZdsyw0AQY5kEzktDBKuBi2XTQGmruiXVUmrKBDe0LokgllVAmqbVUB2is7_cMQwfGWJSvYsGuk57GHJUQkgiaU0no_gzmjDEGMCqMbheh7WiRP1OoLYTKMrUZgIl5USebCpy00O75TY_r34A86GMmQ</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Holubarsch, C</creator><creator>Schmidt-Schweda, S</creator><creator>Knorr, A</creator><creator>Duis, J</creator><creator>Pieske, B</creator><creator>Ruf, T</creator><creator>Fasol, R</creator><creator>Hasenfuss, G</creator><creator>Just, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium</title><author>Holubarsch, C ; Schmidt-Schweda, S ; Knorr, A ; Duis, J ; Pieske, B ; Ruf, T ; Fasol, R ; Hasenfuss, G ; Just, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c240t-7ac12dd5c5e70cf58e662c0759e674bbe2f39d0348a1576c192070f53e0bbdae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Angiotensin I - physiology</topic><topic>Angiotensin II - physiology</topic><topic>Atrial Function</topic><topic>Culture Techniques</topic><topic>Dose-Response Relationship, Drug</topic><topic>Heart Atria - drug effects</topic><topic>Heart Ventricles - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Contraction - physiology</topic><topic>Prazosin - pharmacology</topic><topic>Propranolol - pharmacology</topic><topic>Receptors, Angiotensin - drug effects</topic><topic>Receptors, Angiotensin - physiology</topic><topic>Saralasin - pharmacology</topic><topic>Ventricular Function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holubarsch, C</creatorcontrib><creatorcontrib>Schmidt-Schweda, S</creatorcontrib><creatorcontrib>Knorr, A</creatorcontrib><creatorcontrib>Duis, J</creatorcontrib><creatorcontrib>Pieske, B</creatorcontrib><creatorcontrib>Ruf, T</creatorcontrib><creatorcontrib>Fasol, R</creatorcontrib><creatorcontrib>Hasenfuss, G</creatorcontrib><creatorcontrib>Just, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holubarsch, C</au><au>Schmidt-Schweda, S</au><au>Knorr, A</au><au>Duis, J</au><au>Pieske, B</au><au>Ruf, T</au><au>Fasol, R</au><au>Hasenfuss, G</au><au>Just, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>15 Suppl D</volume><issue>suppl D</issue><spage>88</spage><epage>91</epage><pages>88-91</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>We studied the effects of angiotensin (Ang) I and II in a variety of isolated human cardiac tissues contracting under physiological conditions (37 degrees C, 60 beats.min-1). Ang I and II consistently increased the peak developed force of human atrial muscles by 30-40%, an effect that was completely blocked by 10(-6) M saralasine, but not by the combination of prazosin and propranolol. However, neither Ang I or II had significant inotropic effects in right and left ventricular human preparations. We were also able to demonstrate that the positive inotropic effect of Ang II in human right atrial tissue is mediated by the AT1 receptor subtype but not the AT2 receptor subtype.</abstract><cop>England</cop><pmid>7713120</pmid><doi>10.1093/eurheartj/15.suppl_D.88</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 1994-12, Vol.15 Suppl D (suppl D), p.88-91 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77808191 |
| source | Oxford University Press Archive |
| subjects | Angiotensin I - physiology Angiotensin II - physiology Atrial Function Culture Techniques Dose-Response Relationship, Drug Heart Atria - drug effects Heart Ventricles - drug effects Hemodynamics - drug effects Hemodynamics - physiology Humans Myocardial Contraction - drug effects Myocardial Contraction - physiology Prazosin - pharmacology Propranolol - pharmacology Receptors, Angiotensin - drug effects Receptors, Angiotensin - physiology Saralasin - pharmacology Ventricular Function |
| title | Functional significance of angiotensin receptors in human myocardium. Significant differences between atrial and ventricular myocardium |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T13%3A30%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20significance%20of%20angiotensin%20receptors%20in%20human%20myocardium.%20Significant%20differences%20between%20atrial%20and%20ventricular%20myocardium&rft.jtitle=European%20heart%20journal&rft.au=Holubarsch,%20C&rft.date=1994-12-01&rft.volume=15%20Suppl%20D&rft.issue=suppl%20D&rft.spage=88&rft.epage=91&rft.pages=88-91&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/eurheartj/15.suppl_D.88&rft_dat=%3Cproquest_cross%3E77808191%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c240t-7ac12dd5c5e70cf58e662c0759e674bbe2f39d0348a1576c192070f53e0bbdae3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=77808191&rft_id=info:pmid/7713120&rfr_iscdi=true |