Structuring cell-cycle biology

The recent determination of the crystal structures of both cyclin A and the cyclin A–CDK2 complex provides new insight into the cyclin-dependent activation of cyclin-dependent protein kinases.

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Bibliographic Details
Published in:Structure 1995-11, Vol.3 (11), p.1131-1134
Main Authors: Levine, Kristi, Cross, Frederick R
Format: Article
Language:English
Subjects:
Animals
CDC2-CDC28 Kinases
Cell Cycle - physiology
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases - chemistry
Cyclin-Dependent Kinases - metabolism
Cyclins - chemistry
Cyclins - metabolism
Eukaryotic Cells - cytology
Phosphorylation
Protein Binding
Protein Conformation
Protein Processing, Post-Translational
Protein-Serine-Threonine Kinases - chemistry
Protein-Serine-Threonine Kinases - metabolism
Structure-Activity Relationship
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Description
Summary:The recent determination of the crystal structures of both cyclin A and the cyclin A–CDK2 complex provides new insight into the cyclin-dependent activation of cyclin-dependent protein kinases.
ISSN:0969-2126
1878-4186
DOI:10.1016/S0969-2126(01)00248-9