Modulation of Langerhans cell function by epidermal nerves

Many if not most epidermal Langerhans cells appeared to be closely associated anatomically with calcitonin gene-related peptide (CGRP)-containing nerves as determined by confocal laser scanning microscopy. Furthermore, a small proportion of Langerhans cells had immunoreactive CGRP at or near their c...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1995-12, Vol.96 (6), p.1178-1182
Main Authors: Asahina, A., Hosoi, J., Grabbe, S., Granstein, R.D.
Format: Article
Language:English
Subjects:
and mouse
Animals
antigen presentation
Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation
Biological and medical sciences
Calcitonin gene-related peptide
Calcitonin Gene-Related Peptide - physiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Langerhans cells
Langerhans Cells - physiology
Mice
Molecular immunology
nerve
Skin - innervation
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Summary:Many if not most epidermal Langerhans cells appeared to be closely associated anatomically with calcitonin gene-related peptide (CGRP)-containing nerves as determined by confocal laser scanning microscopy. Furthermore, a small proportion of Langerhans cells had immunoreactive CGRP at or near their cell surfaces, suggesting that nerves are capable of depositing CGRP at or near Langerhans cells. CGRP inhibited Langerhans cell antigen-presenting capability for elicitation of delayed-type hypersensitivity in immunized mice to present alloantigens in the mixed epidermal cell-lymphocyte reaction and to present a protein antigen to a responsive hybridoma. As a whole, these data suggest the possibility that products of nerves within the epidermis might serve to regulate Langerhans cell function. The apparent apposition of epidermal nerves with Langerhans cells suggests a possible locus of interaction between the nervous system and the immune system within the skin. (J A LLERGY C LIN I MMUNOL 1995;96:1178-82.)
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(95)70203-2