Novel prostanoid thromboxane A2 agonists

The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 1...

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Bibliographic Details
Published in:Prostaglandins 1995-08, Vol.50 (2), p.57-63
Main Authors: Joachim, K D, Klar, U, Pletsch, A, Rehwinkel, H, Skuballa, W
Format: Article
Language:English
Subjects:
Blood Platelets - metabolism
Cell Membrane - metabolism
Humans
Platelet Aggregation - drug effects
Prostaglandins D - chemical synthesis
Prostaglandins D - pharmacology
Receptors, Thromboxane - metabolism
Thromboxane A2 - agonists
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Summary:The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor against U 46619.
ISSN:0090-6980
DOI:10.1016/0090-6980(95)00048-8