Comparison of the in vitro activity of levofloxacin and other antimicrobial agents against vancomycin-susceptible and vancomycin resistant Enterococcus species

The in vitro activities of levofloxacin and other antibiotics against 133 clinical isolates of vancomycin-resistant and vancomycin-susceptible enterococci were evaluated. Only 14 (39%) of the vancomycin-susceptible isolates and 11 (11%) of the vancomycin-resistant isolates were susceptible to levofl...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1995-08, Vol.22 (4), p.349-352
Main Authors: Hayden, Mary K., Matushek, Marian G., Trenholme, Gordon M.
Format: Article
Language:English
Subjects:
Ampicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ciprofloxacin - pharmacology
Drug Resistance, Microbial
Enterococcus - drug effects
Levofloxacin
Medical sciences
Microbial Sensitivity Tests
Ofloxacin - pharmacology
Penicillins - pharmacology
Pharmacology. Drug treatments
Vancomycin - pharmacology
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Summary:The in vitro activities of levofloxacin and other antibiotics against 133 clinical isolates of vancomycin-resistant and vancomycin-susceptible enterococci were evaluated. Only 14 (39%) of the vancomycin-susceptible isolates and 11 (11%) of the vancomycin-resistant isolates were susceptible to levofloxacin. Levofloxacin exhibited a marked inoculum effect for all enterococci tested. These results suggest that levofloxacin may be of limited use in the treatment of serious enterococcal infections.
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(95)00144-1