The effect of hypercholesterolemia on the sodium inward currents in cardiac myocyte

To determine whether chronic hypercholesterolemia affects sodium inward currents in cardiac myocytes, whole-cell clamp recordings were made in single cardiac myocytes isolated from normo- and hypercholesterolemic rabbits. Modification of the serum cholesterol was accomplished by feeding ten 3-month-...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 1995-06, Vol.27 (6), p.1263-1269
Main Authors: Wu, Chau-Chung, Su, Ming-Jai, Chi, Jo-Feng, Chen, Wen-Jone, Hsu, Hsiu-Ching, Lee, Yuan-Teh
Format: Article
Language:English
Subjects:
Animals
Hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - metabolism
In Vitro Techniques
Ion Transport
Kinetics
Lipid Metabolism
Lipids - blood
Male
Myocardium - cytology
Myocardium - metabolism
Rabbits
Sarcolemma - metabolism
Sodium - metabolism
Sodium Channel Blockers
Sodium Channels - metabolism
Sodium inward current
Whole-cell clamp
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Summary:To determine whether chronic hypercholesterolemia affects sodium inward currents in cardiac myocytes, whole-cell clamp recordings were made in single cardiac myocytes isolated from normo- and hypercholesterolemic rabbits. Modification of the serum cholesterol was accomplished by feeding ten 3-month-old male New Zealand white rabbits with control diet (group I) and ten with 0.5% cholesterol-enriched diet (group II), for 3 months. The serum cholesterol levels of group II were much higher than those of group I (2042±231 v 82±9 mg/dl, P
ISSN:0022-2828
1095-8584
DOI:10.1016/S0022-2828(05)82388-0