Allogeneic transfusion risks in the surgical patient

The risk of blood transfusion-associated complications has been reduced in the past 10 years through technical advances in testing of blood, viral inactivation of noncellular blood components, enforcement of stringent donor selection criteria, and the use of alternatives to allogeneic transfusion. E...

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Bibliographic Details
Published in:The American journal of surgery 1995-12, Vol.170 (6), p.S21-S26
Main Author: Klein, Harvey G.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - transmission
AIDS/HIV
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antigen-Antibody Reactions - immunology
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Erythrocytes - immunology
Graft vs Host Disease - etiology
Hepatitis, Viral, Human - transmission
HTLV-I Infections - transmission
Humans
Immune Tolerance - immunology
Medical sciences
Risk
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation, Homologous - adverse effects
Transplantation, Homologous - immunology
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Summary:The risk of blood transfusion-associated complications has been reduced in the past 10 years through technical advances in testing of blood, viral inactivation of noncellular blood components, enforcement of stringent donor selection criteria, and the use of alternatives to allogeneic transfusion. Even so, a zero-risk blood supply is unfeasible. The general public perceives infectious complications to be the most significant risk: although the greatest fear is associated with transmission of human immunodeficiency virus (HIV), at least three hepatitis viruses are transmissible by all blood components. Human immunodeficiency virus accounts for
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(99)80054-3