Ceftriaxone effect on bilirubin-albumin binding

The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 X 10(4)...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1987-12, Vol.80 (6), p.873-875
Main Authors: FINK, S, KARP, W, ROBERTSON, A
Format: Article
Language:English
Subjects:
Adult
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bilirubin - blood
Binding, Competitive
Biological and medical sciences
Ceftriaxone - blood
Ceftriaxone - pharmacology
Dapsone - analogs & derivatives
Dapsone - blood
Fetal Blood - metabolism
Humans
In Vitro Techniques
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Serum Albumin - metabolism
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Summary:The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 X 10(4) L/mol. Therapeutic levels of ceftriaxone decrease the reserve albumin concentration in newborn serum by 39%. These results indicate that ceftriaxone may increase the risk of bilirubin encephalopathy in jaundiced premature infants.
ISSN:0031-4005
1098-4275