Different Localization of Tau Protein Kinase I/Glycogen Synthase Kinase-3β from Glycogen Synthase Kinase-3α in Cerebellum Mitochondria

We examined the subcellular distribution of two glycogen synthase kinase-3 (GSK-3) isoforms in rat cerebellum. Results from immunoelectron microscopy and subcellular fractionation revealed that one isoform, tau protein kinase I/GSK-3β (TPKI/GSK-3β), was present in mitochondria, but GSK-3α was not. A...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1995-10, Vol.118 (4), p.683-685
Main Authors: Hoshi, Minako, Sato, Michio, Kondo, Shunzo, Takashima, Akihiko, Noguchi, Kaori, Takahashi, Miho, Ishiguro, Koichi, Imahori, Kazutomo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Calcium-Calmodulin-Dependent Protein Kinases - analysis
Cell Compartmentation
Cerebellum - enzymology
Cerebellum - ultrastructure
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
immunoelectron microscope
Microscopy, Immunoelectron
mitochondria
Mitochondria - enzymology
Mitochondria - ultrastructure
neuronal death
Protein-Serine-Threonine Kinases - analysis
Rats
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Summary:We examined the subcellular distribution of two glycogen synthase kinase-3 (GSK-3) isoforms in rat cerebellum. Results from immunoelectron microscopy and subcellular fractionation revealed that one isoform, tau protein kinase I/GSK-3β (TPKI/GSK-3β), was present in mitochondria, but GSK-3α was not. Although the two GSK-3 isoforms seem to have similar properties, the difference of subcellular localization observed here suggests that TPKI/GSK-3β fulfills some specific function in mitochondria.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a124965