Nerve Terminal Remodeling Visualized in Living Mice by Repeated Examination of the Same Neuron

The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or the synapses on them; these procedures could...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1987-11, Vol.238 (4830), p.1122-1126
Main Authors: Purves, Dale, Voyvodic, James T., Magrassi, Lorenzo, Yawo, Hiromu
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Autonomic ganglia
Biological and medical sciences
Biology
Coloring Agents
Dyes
Fluorescence
Fluorescent Dyes
Fundamental and applied biological sciences. Psychology
Ganglia
Ganglia, Autonomic
Ganglia, Parasympathetic - cytology
Ganglia, Parasympathetic - physiology
House mouse
Imaging
Isolated neuron and nerve. Neuroglia
Membrane Potentials
Mice
Mice as laboratory animals
Nerve endings
Nerve Endings - ultrastructure
Nerves
Nervous system
Neuronal Plasticity
Neurons
Pixels
Pyridinium Compounds
Rodents
Synapses
Time Factors
Vertebrates: nervous system and sense organs
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Summary:The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or the synapses on them; these procedures could therefore be repeated after an arbitrary period. Observations of the same neurons at intervals of up to 3 weeks indicate that the pattern of preganglionic terminals on many of these nerve cells gradually changes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3685967