Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sensory ganglia: a comparative study

In rats, the distribution of nerve structures staining for NADPH-diaphorase, and showing immunoreactivities for nitric oxide synthase (NOS), tyrosine hydroxylase and various neuropeptides was studied in sensory ganglia (dorsal root, nodose and trigeminal ganglia), in sympathetic ganglia (superior ce...

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Bibliographic Details
Published in:The Histochemical journal 1995-10, Vol.27 (10), p.819-831
Main Authors: Alm, P, Uvelius, B, Ekström, J, Holmqvist, B, Larsson, B, Andersson, K E
Format: Article
Language:English
Subjects:
Animals
Female
Ganglia, Parasympathetic - enzymology
Ganglia, Parasympathetic - ultrastructure
Ganglia, Sensory - enzymology
Ganglia, Sensory - ultrastructure
Ganglia, Sympathetic - enzymology
Ganglia, Sympathetic - ultrastructure
Immunohistochemistry
Male
NADPH Dehydrogenase - metabolism
Nerve Fibers - enzymology
Neurons - enzymology
Neurons - ultrastructure
Neuropeptides - analysis
Nitric Oxide Synthase - analysis
Rats
Tyrosine 3-Monooxygenase - analysis
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Summary:In rats, the distribution of nerve structures staining for NADPH-diaphorase, and showing immunoreactivities for nitric oxide synthase (NOS), tyrosine hydroxylase and various neuropeptides was studied in sensory ganglia (dorsal root, nodose and trigeminal ganglia), in sympathetic ganglia (superior cervical, stellate, coeliac-superior and inferior mesenteric ganglia), parasympathetic ganglia (sphenopalatine, submandibular, sublingual and otic ganglia), and in the mixed parasympathetic/sympathetic ganglia (major pelvic ganglia). The coincidence of neuronal cell bodies with strong NOS-immunoreactivity and strong NADPH diaphorase reactivity was almost total. The relative proportions of NOS-immunoreactive nerve cell bodies were largest in parasympathetic ganglia and major pelvic ganglia followed by sensory ganglia. In sympathetic ganglia no NOS-immunoreactive neuronal cell bodies could be detected. In parasympathetic and major pelvic ganglia, there was a very significant neuronal co-localization of immunoreactivities for NOS and vasoactive intestinal polypeptide (VIP). This was almost total in major pelvic ganglia, in which NOS-/VIP-immunoreactive nerve cell bodies were separate from sympathetic (tyrosine hydroxylase-/neuropeptide Y-immunoreactive), suggesting that NOS-/VIP-immuno-reactive neurons might also be parasympathetic.
ISSN:0018-2214
1573-6865
DOI:10.1007/bf02388306