The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development

Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 1995-11, Vol.17 (5), p.437-445
Main Authors: POPOFF, S. N, MARKS, S. C
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - physiology
Animals
Biological and medical sciences
Bone Development - physiology
Bone Resorption - genetics
Bone Resorption - physiopathology
Diseases of the osteoarticular system
Macrophage Colony-Stimulating Factor - physiology
Malformations and congenital and or hereditary diseases involving bones. Joint deformations
Medical sciences
Mutation - genetics
Osteopetrosis - genetics
Osteopetrosis - physiopathology
Proto-Oncogene Proteins - physiology
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Summary:Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.
ISSN:8756-3282
1873-2763
DOI:10.1016/8756-3282(95)00347-4