Three-Dimensional Structure of Interleukin-2

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1987-12, Vol.238 (4834), p.1707-1709
Main Authors: Brandhuber, Barbara J., Boone, Tom, Kenney, William C., McKay, David B.
Format: Article
Language:English
Subjects:
Analysis
Analysis of the immune response. Humoral and cellular immunity
Animals
Atoms
Binding sites
Biochemistry
Biological and medical sciences
Crystal twinning
Crystals
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Interleukin-2
Interleukin-2 - isolation & purification
Interleukins
Lymphokines, interleukins ( function, expression)
man
Mice
Models, Molecular
Molecular structure
Molecules
Phenyls
Protein Conformation
Proteins
Receptors
Regulatory factors and their cellular receptors
Solvents
T lymphocytes
X-Ray Diffraction
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Summary:Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3500515