Achromatic neurons in the cortex of progressive supranuclear palsy

Achromatic neurons (AN) in the cerebral cortex are a characteristic feature of several neurodegenerative conditions including Pick's disease, corticobasal degeneration and some cases of primary progressive aphasia. Although AN are occasionally seen in some other diseases, their presence in prog...

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Bibliographic Details
Published in:Acta neuropathologica 1995-12, Vol.90 (6), p.615-619
Main Authors: MACKENZIE, I. R. A, HUDSON, L. P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cerebral Cortex - pathology
Cerebral Cortex - ultrastructure
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Nervous System Diseases - pathology
Neurofibrillary Tangles - pathology
Neurology
Neurons - ultrastructure
Supranuclear Palsy, Progressive - pathology
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Summary:Achromatic neurons (AN) in the cerebral cortex are a characteristic feature of several neurodegenerative conditions including Pick's disease, corticobasal degeneration and some cases of primary progressive aphasia. Although AN are occasionally seen in some other diseases, their presence in progressive supranuclear palsy (PSP) has not been previously documented. We found significant numbers of AN in the cerebral cortex of five out of seven cases which had been diagnosed pathologically as PSP. The identification of AN was greatly facilitated by the use of neurofilament immunohistochemistry. The entorhinal and transentorhinal cortices were most frequently involved, but in several cases AN were also seen throughout the neocortex. The presence and number of AN roughly correlated with a history of clinical dementia. This suggests that cortical AN may be a common and important pathological finding in PSP.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00318574