Antibodies to human optic nerve in Leber's hereditary optic neuropathy

Mutations of mitochondrial DNA have now been identified in the majority of patients with Leber's hereditary optic neuropathy (LHON). However, these mutations do not explain all the clinical features of LHON, and other pathogenetic factors are likely to be operating. We have analysed serum from...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 1995-06, Vol.130 (2), p.134-138
Main Authors: Smith, P.R., Cooper, J.M., Govan, G.G., Riordan-Eva, P., Harding, A.E., Schapira, A.H.V.
Format: Article
Language:English
Subjects:
Adult
Antigens - analysis
Autoantibodies - analysis
Autoimmunity
Autoimmunity - immunology
Biological and medical sciences
Diseases of visual field, optic nerve, optic chiasma and optic tracts
Electrophoresis, Polyacrylamide Gel
Female
Humans
Hydrogen-Ion Concentration
Immunoblotting
Leber's hereditary optic neuropathy
Male
Medical sciences
Mitochondria
Ophthalmology
Optic Atrophies, Hereditary - immunology
Optic nerve
Optic Nerve - immunology
Precipitin Tests
Tubulin - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mutations of mitochondrial DNA have now been identified in the majority of patients with Leber's hereditary optic neuropathy (LHON). However, these mutations do not explain all the clinical features of LHON, and other pathogenetic factors are likely to be operating. We have analysed serum from 69 LHON patients and their relatives, 58 controls and 14 patients with ischemic or compressive optic neuropathy. A significant proportion of LHON patients had circulating antibodies to tubulin protein. This finding supports the theory that autoimmunity may play some role in the pathogenesis of LHON.
ISSN:0022-510X
1878-5883
DOI:10.1016/0022-510X(95)00021-S