Behaviorally conditioned anorexia: Role of gastric emptying and prostaglandins

The reduction of food intake in response to bacteria is posited to be a favourable host reaction. This report attempted to examine whether gastric emptying is involved in the known conditionability of this response. Additionally, this study investigated the role of prostaglandins in the conditioned...

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Bibliographic Details
Published in:Physiology & behavior 1995-09, Vol.58 (3), p.471-476
Main Authors: Exton, Michael S., Lightfoot, Jeanette B., Stanton, Matthew W., Bull, Diane F., King, Maurice G., Husband, Alan J.
Format: Article
Language:English
Subjects:
Animals
Anorexia
Appetite - physiology
Association Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Conditioned taste aversion
Conditioning
Conditioning, Classical - physiology
Eating - physiology
Endotoxin
Feeding
Fundamental and applied biological sciences. Psychology
Gastric emptying
Gastric Emptying - physiology
Hunger - physiology
Immunomodulator
Interleukin-1
Lipopolysaccharide
Lipopolysaccharides
LPS
Male
Miscellaneous
Prostaglandin
Prostaglandins - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Saccharin
Taste - physiology
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Summary:The reduction of food intake in response to bacteria is posited to be a favourable host reaction. This report attempted to examine whether gastric emptying is involved in the known conditionability of this response. Additionally, this study investigated the role of prostaglandins in the conditioned anorexic response. To investigate this phenomenon, lipopolysaccharide (LPS) (100 μg/kg) was used as the uncoditioned stimulus, and paired with a novel 1% saccharin solution (conditioned stimulus). Upon conditioned stimulus (CS) representation, experimental animals displayed a marked reduction in food consumption (experiment 1) and emptying of gastric contents (experiment 2). Additionally, treatment with indomethacin upon CS reexposition blocked both the conditioned anorexia and suppression of gastric emptying. These results indicate that conditioned anorexia is possibly the result of a conditioned inhibition of gastric emptying, and this process is mediated by conditioned alterations in PG levels.
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(95)00088-Z