The inflammatory effect of nucleus pulposus: a possible element in the pathogenesis of low-back pain

Homogenized autogenous nucleus pulposus was injected into the lumbar epidural space of four dogs through an indwelling catheter. After daily injections of the material over 5 to 7 days, the dogs were killed at 5, 7, 14, or 21 days after the first injection. In four dogs that served as controls, norm...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1987-10, Vol.12 (8), p.760-764
Main Authors: MCCARRON, R. F, WIMPEE, M. W, HUDKINS, P. G, LAROS, G. S
Format: Article
Language:English
Subjects:
Animals
Back Pain - etiology
Biological and medical sciences
Diseases of the osteoarticular system
Diseases of the spine
Dogs
Dura Mater
Female
Intervertebral Disc Displacement - complications
Male
Medical sciences
Meningitis - etiology
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Summary:Homogenized autogenous nucleus pulposus was injected into the lumbar epidural space of four dogs through an indwelling catheter. After daily injections of the material over 5 to 7 days, the dogs were killed at 5, 7, 14, or 21 days after the first injection. In four dogs that served as controls, normal saline was injected on an identical schedule and the dogs were killed at times identical to the experimental group. Evaluation of the dural sac, the spinal cord and its roots was performed by gross inspection and microscopic analysis. There was evidence of an inflammatory response to the nuclear material injected, but no inflammatory response occurred in the control group.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-198710000-00009