Lymphotoxin is an Important T Cell-Derived Growth Factor for Human B Cells

Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1987-11, Vol.238 (4830), p.1144-1146
Main Authors: Kehrl, John H., Alvarez-Mon, Melchor, Delsing, Gita A., Fauci, Anthony S.
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Antibodies
Antibody Formation - drug effects
B cells
B lymphocytes
B-Lymphocytes - cytology
Biological and medical sciences
Biology
Cell Differentiation - drug effects
Cell growth
Cell proliferation
Cells, Cultured
Cultured cells
DNA - biosynthesis
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Growth
Growth factors
Growth Substances - physiology
Human growth
Humans
Immune response
Immunobiology
In Vitro Techniques
Interleukin-4
Interleukins
Lymphocyte Activation
Lymphokines, interleukins ( function, expression)
Lymphotoxin-alpha - physiology
Recombinant Proteins - pharmacology
Regulatory factors and their cellular receptors
Secretion
T cells
T lymphocytes
T-Lymphocytes - physiology
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Summary:Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3500512