p53 tumor suppressor gene protein expression in cervical cancer: relationship to prognosis

Objective: Mutation of the p53 gene can be found in several human tumors. We tested the hypothesis whether overexpression of p53 protein is a parameter of more aggressive disease in patients with cervical cancer. Study design: In this study, we describe the effects of p53 overexpression in 156 patie...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 1995-11, Vol.63 (1), p.55-59
Main Authors: Bremer, Gerard L., Tieboschb, Anton T.M.G., van der Putten, Hans W.H.M., de Haan, Jelte, Arends, Jan-Willem
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biological and medical sciences
Cervical Cancer
Female
Gene Expression
Genes, p53
Genital system. Mammary gland
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Lymph Nodes - pathology
Lymphatic Metastasis
Medical sciences
Mutation
Neoplasm Staging
p53
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prognosis
Survival
Survival Rate
Tumor suppressor gene
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - pathology
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Summary:Objective: Mutation of the p53 gene can be found in several human tumors. We tested the hypothesis whether overexpression of p53 protein is a parameter of more aggressive disease in patients with cervical cancer. Study design: In this study, we describe the effects of p53 overexpression in 156 patients with cervical cancer (Figo stage IB-IV) by assessing expression patterns of the p53 gene product using a monoclonal anti-p53 antibody (DO7). Results: Overexpression of p53 tumor suppressor gene protein was observed in 30.2% of the tumors, low expression in 30.7% and 39.1% of the tumors showed no p53 immunoreactivity. With increase in stage, p53 overexpression raised from 20.1% in stage IB to 60% in stage IV. A significant correlation between p53 overexpression and disease-free survival of patients was observed, however, after stratification for stage, this effect disappeared. Conclusions: The p53 mutation expressed as p53 tumor suppressor gene protein overexpression is a late event in cervical cancer genesis and does not appear to be of prognostic significance in cervical cancer.
ISSN:0301-2115
1872-7654
DOI:10.1016/0301-2115(95)02225-V