Excitation and Inhibition via Adenosine Receptors of the Twitch Response to Electrical Stimulation in Isolated Guinea Pig Ileum

The effects of adenosine and its related compounds on the cholinergic twitch response were examined in electrically stimulated guinea pig ileum. Adenosine (3×10-7-10-5 M) and an adenosine A1-receptor agonist N6-cyclohexyladenosine (CHA, 10-8-10-6 M) suppressed the twitch. Conversely, the A2a-recepto...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1995, Vol.69(4), pp.429-433
Main Authors: Tomaru, Atsushi, Ina, Yasuhiro, Kishibayashi, Nobuyuki, Karasawa, Akira
Format: Article
Language:English
Subjects:
Adenosine - pharmacology
Adenosine receptor
Animals
Cholinergic Fibers - drug effects
Dose-Response Relationship, Drug
Electric Stimulation
Guinea Pigs
Ileum
Ileum - drug effects
Ileum - physiology
Male
Receptors, Purinergic P1 - drug effects
Twitch response
Xanthines - pharmacology
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Summary:The effects of adenosine and its related compounds on the cholinergic twitch response were examined in electrically stimulated guinea pig ileum. Adenosine (3×10-7-10-5 M) and an adenosine A1-receptor agonist N6-cyclohexyladenosine (CHA, 10-8-10-6 M) suppressed the twitch. Conversely, the A2a-receptor agonist 2-[p-(2-carboxyethyl)phenethylamino]-5’-N-ethylcarboxamidoadenosine (CGS 21680, 10-9-10-7M) potentiated the twitch in half the preparations examined. The A1-antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), which per se did not affect the twitch, recovered the attenuated twitch caused by CHA (10-7 M) or adenosine (10-6 M) and converted it into a potentiated twitch. These results suggest the presence of adenosine A1- and A2a-receptors coupled negatively and positively, respectively, to acetylcholine release in the preparation.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.69.429