Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs

The antiarthritic potential of two different acyclic nucleotide analogs, i.e. 9-(2-phosphonomethoxyethyl)adenine (PMEA), its bis(pivaloyloxymethyl)ester (Bis-POM-PMEA), and 1-( S)-(3-hydroxy-2-phosphonomethoxyethyl) cytosine (HPMPC) was investigated in the rat model of mycobacterial adjuvant-induced...

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Bibliographic Details
Published in:European journal of pharmacology 1995-11, Vol.286 (3), p.307-310
Main Authors: ZIDEK, Z, HOLY, A, FRANKOVA, D, OTOVA, B
Format: Article
Language:English
Subjects:
Acyclic nucleotide analog
Adenine - analogs & derivatives
Adenine - therapeutic use
Adjuvant arthritis
Animals
Antiarthritic effect
Arthritis, Experimental - prevention & control
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cidofovir
Cytosine - analogs & derivatives
Cytosine - therapeutic use
Female
HPMPC (1-( S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine)
Medical sciences
Organophosphonates
Organophosphorus Compounds - therapeutic use
Pharmacology. Drug treatments
PMEA (9-(2-phosphonomethoxyethyl)adenine)
Rats
Rats, Inbred BN
Rats, Inbred Lew
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Summary:The antiarthritic potential of two different acyclic nucleotide analogs, i.e. 9-(2-phosphonomethoxyethyl)adenine (PMEA), its bis(pivaloyloxymethyl)ester (Bis-POM-PMEA), and 1-( S)-(3-hydroxy-2-phosphonomethoxyethyl) cytosine (HPMPC) was investigated in the rat model of mycobacterial adjuvant-induced arthritis. With dependence on the dose, timing and route of administration, as well as on the genetic constitution of the arthritis-prone animals, PMEA was able to delay the onset, and substantially reduce or nearly completely inhibit the development of arthritic paw swelling. HPMPC was less active in this model. As compared with PMEA, its prodrug, Bis-POM-PMEA, expressed much more pronounced beneficial effects after both oral and i.p. administration.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(95)00586-3