ACTION OF ITURIN A, AN ANTIFUNGAL ANTIBIOTIC FROM BACILLUS SUBTILIS, ON THE YEAST SACCHAROMYCES CEREVISIAE: MODIFICATIONS OF MEMBRANE PERMEABILITY AND LIPID COMPOSITION

The action of iturin A on non-growing cells of Saccharomyces cerevisiae was tested. This antibiotic gave important modifications in the membrane permeability which permitted nucleotides, proteins, polysaccharides and lipids to escape from cells. The lipid content of cells was strongly disturbed; the...

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Bibliographic Details
Published in:Journal of antibiotics 1987/11/25, Vol.40(11), pp.1588-1595
Main Authors: LATOUD, CHANTAL, PEYPOUX, FRANCHISE, MICHEL, GEORGES
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacokinetics
Biological and medical sciences
Cell Membrane Permeability - drug effects
iturin A
lipid composition
Medical sciences
membrane permeability
Peptides
Peptides, Cyclic - pharmacokinetics
Pharmacology. Drug treatments
Phospholipids - analysis
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
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Summary:The action of iturin A on non-growing cells of Saccharomyces cerevisiae was tested. This antibiotic gave important modifications in the membrane permeability which permitted nucleotides, proteins, polysaccharides and lipids to escape from cells. The lipid content of cells was strongly disturbed; the level of phospholipids, essentially phosphatidylcholine, decreased while the level of fatty acids increased. A part of these fatty acids were extruded from yeast cells. The role of iturin A in these modifications was discussed.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.1588