Thyroid hormone uptake into the cell and its subsequent localisation to the mitochondria

The nature of thyroid hormone uptake into the cell and the possible involvement of the serum carrier proteins and receptor-mediated endocytosis in this process are reviewed. The evidence that there is a specific thyroid hormone-binding receptor in the inner mitochondrial membrane and the relation of...

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Bibliographic Details
Published in:FEBS Letters 1987-11, Vol.224 (2), p.251-256
Main Author: Hafner, Roderick P.
Format: Article
Language:English
Subjects:
Active transport
Adenine nucleotide translocator
Animals
Biological and medical sciences
Biological Transport, Active
Carrier Proteins - metabolism
Cell Membrane - metabolism
Endocytosis
Fundamental and applied biological sciences. Psychology
Hormones. Regulation
Mitochondria
Mitochondria - metabolism
Mitochondrial ADP, ATP Translocases - physiology
Receptor
T3, 3,5,3′-triiodo-L-thyronine
T4, L-thyroxine
Thyroid hormone
thyroid hormones
Thyroid Hormones - metabolism
Thyroid. Parathyroid. Ultimobranchial body
Vertebrates: endocrinology
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Summary:The nature of thyroid hormone uptake into the cell and the possible involvement of the serum carrier proteins and receptor-mediated endocytosis in this process are reviewed. The evidence that there is a specific thyroid hormone-binding receptor in the inner mitochondrial membrane and the relation of this to the adenine nucleotide translocator is discussed. Direct effects of thyroid hormone on mitochondrial function that might be mediated by such a receptor are also considered.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(87)80464-7