A modified pharmacokinetic model for platinum disposition in ovarian cancer patients receiving cisplatin

We have fitted a first-order multicompartment pharmacokinetic model to plasma platinum concentrations measured in nine ovarian cancer patients who received intravenous infusions of cisplatin for 6 h. The time-course of ultrafilterable plasma platinum was similar in all patients studied, and was fitt...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1987, Vol.33 (1), p.67-72
Main Authors: GRIFFITHS, H, SHELLEY, M. D, FISH, R. G
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Cisplatin - blood
Cisplatin - pharmacokinetics
Cisplatin - therapeutic use
Female
Humans
Kidney - metabolism
Medical sciences
Metabolic Clearance Rate
Middle Aged
Models, Biological
Ovarian Neoplasms - blood
Ovarian Neoplasms - drug therapy
Pharmacology. Drug treatments
Platinum - blood
Protein Binding
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Summary:We have fitted a first-order multicompartment pharmacokinetic model to plasma platinum concentrations measured in nine ovarian cancer patients who received intravenous infusions of cisplatin for 6 h. The time-course of ultrafilterable plasma platinum was similar in all patients studied, and was fitted by a single compartment within the limits of experimental detection. However, the time-course of protein-bound platinum showed marked differences between patients, the differences being explained by distribution to two peripheral compartments. The wide inter-patient variation observed in protein-bound plasma platinum concentrations supports the view that pharmacokinetic modelling should be carried out separately for each patient, since averaging plasma concentrations would have obscured some individual pharmacokinetic characteristics.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00610382