Left ventricular systolic function after marked reduction of ventricular hypertrophy induced by 5 years' enalapril treatment

• Published in: European heart journal 1995-12, Vol.16 (12), p.1981-1987
• Main Authors: GONZÁLEZ-JUANATEY, J. R., REINO, A. POSE, ACUÑA, J. M. GARCÍA, FUENTES, V. CASTELO, GENDÓN, A. AMARO, GÓMEZ, C. CALVO, GIL DE LA PEÑA, M.
• Format: Article
• Language: English
• Subjects: Adult; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Antihypertensive agents; Biological and medical sciences; Cardiovascular system; Echocardiography - drug effects; enalapril; Enalapril - administration & dosage; Enalapril - adverse effects; Female; Follow-Up Studies; Hemodynamics - drug effects; Hemodynamics - physiology; Humans; Hypertension - diagnostic imaging; Hypertension - drug therapy; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - drug therapy; left ventricular systolic function; Long-Term Care; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Ventricular Function, Left - drug effects; Ventricular Function, Left - physiology; Ventricular hypertrophy
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/oxfordjournals.eurheartj.a060857

Objectives To determine the effects of long-term treatment of essential hypertension with an angiotensin-converting enzyme inhibitor as regards arterial pressure at rest and during exercise, left ventricular mass and functional sequelae. Patients and Methods Twenty-six patients with previously untreated essential hypertension took enalapril 20 mg twice daily for 5 years. Cardiovascular parameters were determined by two-dimensionally guided M-mode echocardiography in a pre-treatment placebo phase, 8 weeks and 1, 3 and 5 years after the start of therapy, and 8 weeks after drugs were discontinued. Results Therapy reduced resting arterial pressure from 156/105 to 128/84 mmHg (P