An Improved Source of Bryostatin 10, Bugula neritina from the Gulf of Aomori, Japan

Bryostatins have been isolated from diverse Japanese coastal specimens of Bugula neritina guided by inhibitory activity against fertilized sea urchin egg cell division. B. neritina from the Gulf of Aomori, Japan, has been found to contain bryostatin 10 [1b] in high yield (10(-3)%) for this class of...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1995-12, Vol.58 (12), p.1868-1875
Main Authors: Kamano, Yoshiaki, Zhang, Hui-Ping, Hino, Akiya, Yoshida, Motoyuki, Pettit, George R, Herald, Cherry L, Itokawa, Hideji
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ANALISIS CUANTITATIVO
ANALYSE QUANTITATIVE
ANIMAL AQUATIQUE
ANIMALES ACUATICOS
Animals
ANTINEOPLASTIC AGENTS
AQUATIC ANIMALS
Biological and medical sciences
Bryostatins
Bryozoa - chemistry
Cattle
Cells, Cultured
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
ESPECTROMETRIA
General pharmacology
GULF OF OHZUCHI
GULF OF SAGAMI
INVERTEBRADOS
INVERTEBRATES
INVERTEBRE
Japan
LACTONAS
LACTONE
LACTONES
Lactones - chemistry
Lactones - isolation & purification
Macrolides
Magnetic Resonance Spectroscopy
MAR DEL JAPON
Medical sciences
MEDICAMENT CYTOSTATIQUE
MER DU JAPON
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
QUANTITATIVE ANALYSIS
SEA OF JAPAN
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Steroids - biosynthesis
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Description
Summary:Bryostatins have been isolated from diverse Japanese coastal specimens of Bugula neritina guided by inhibitory activity against fertilized sea urchin egg cell division. B. neritina from the Gulf of Aomori, Japan, has been found to contain bryostatin 10 [1b] in high yield (10(-3)%) for this class of compounds. The 1H- and 13C-nmr signals of bryostatin 10 [1b] were reassigned by 2D nmr techniques. The conformation of bryostatin 10 [1b] in solution was revealed by nmr studies. This compound also exhibited activity in a steroidogenesis assay by increasing the production of adrenocortical hormones nearly twofold.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50126a009