Role of immunoglobulin G subclasses in Q fever

The progression of Q fever to either acute or chronic disease has been attributed both to biological characteristics of the bacteria and to the host immune response. In order to determine whether a specific immunoglobulin G (IgG) subclass distribution could play a diagnostic or prognostic role in Q...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1995-12, Vol.14 (12), p.1070-1075
Main Authors: CAMACHO, M. T, OUTSCHOORN, I, TELLEZ, A
Format: Article
Language:English
Subjects:
Acute Disease
Bacterial diseases
Biological and medical sciences
Chronic Disease
Coxiella burnetii - immunology
Disease Progression
Human bacterial diseases
Humans
Immunoglobulin G - immunology
Immunoglobulin gamma-Chains - analysis
Immunoglobulin gamma-Chains - blood
Immunoglobulin gamma-Chains - immunology
Infectious diseases
Medical sciences
Q Fever - diagnosis
Q Fever - immunology
Rickettsial diseases
Tropical bacterial diseases
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Summary:The progression of Q fever to either acute or chronic disease has been attributed both to biological characteristics of the bacteria and to the host immune response. In order to determine whether a specific immunoglobulin G (IgG) subclass distribution could play a diagnostic or prognostic role in Q fever, IgG subclass levels were measured in patients with acute or chronic disease. It was observed that (i) IgG1 and IgG3 levels were elevated in patients with chronic Q fever compared to patients with acute disease or normal controls; (ii) variations over time reflected inverse complementary relationships of subclass levels, such as between IgG1 and IgG3 compared with IgG2 and IgG4, or an inverse relationship between IgG1 and IgG2; (iii) variations in IgG2 and IgG3 total subclass levels during follow-up of patients with chronic Q fever showed a decrease in IgG2 with a concomitant increase in IgG3 two years from disease onset. These findings indicate that measurements of IgG subclasses may be a simple, additional tool useful in the diagnosis of Q fever. This data raises the question of an unusual immunoregulatory mechanism in Q fever that is implicated in the presentation of the clinical disease.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF01590941