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Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA
An association between non-A, non-B hepatitis and hepatocellular carcinoma has been made on the basis of negative serological markers for hepatitis B virus (HBV); however, hepatocellular carcinomas have been found to contain hepatitis B virus deoxyribonucleic acid (HBV DNA) in individuals who lack s...
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Published in: | Digestive diseases and sciences 1987-12, Vol.32 (12), p.1428-1430 |
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container_end_page | 1430 |
container_issue | 12 |
container_start_page | 1428 |
container_title | Digestive diseases and sciences |
container_volume | 32 |
creator | Cohen, E B Gang, D L Zeldis, J B |
description | An association between non-A, non-B hepatitis and hepatocellular carcinoma has been made on the basis of negative serological markers for hepatitis B virus (HBV); however, hepatocellular carcinomas have been found to contain hepatitis B virus deoxyribonucleic acid (HBV DNA) in individuals who lack serological markers of HBV infection. Therefore, reports which ascribed a hepatocellular carcinoma to non-A, non-B hepatitis but did not examine the tumor for HBV DNA are open to question. We describe a case of chronic active hepatitis with primary hepatocellular carcinoma that lacked HBV DNA in the tumor, the nontumorous liver tissue, and serum. The individual lacked all serological markers for HBV infection. This report more fairly supports the association between hepatocellular carcinoma and chronic hepatitis not due to hepatitis B. Whether this is related specifically to a non-A, non-B hepatitis agent requires identification of the viral agents that cause non-A, non-B hepatitis. |
doi_str_mv | 10.1007/BF01296671 |
format | article |
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Therefore, reports which ascribed a hepatocellular carcinoma to non-A, non-B hepatitis but did not examine the tumor for HBV DNA are open to question. We describe a case of chronic active hepatitis with primary hepatocellular carcinoma that lacked HBV DNA in the tumor, the nontumorous liver tissue, and serum. The individual lacked all serological markers for HBV infection. This report more fairly supports the association between hepatocellular carcinoma and chronic hepatitis not due to hepatitis B. 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Therefore, reports which ascribed a hepatocellular carcinoma to non-A, non-B hepatitis but did not examine the tumor for HBV DNA are open to question. We describe a case of chronic active hepatitis with primary hepatocellular carcinoma that lacked HBV DNA in the tumor, the nontumorous liver tissue, and serum. The individual lacked all serological markers for HBV infection. This report more fairly supports the association between hepatocellular carcinoma and chronic hepatitis not due to hepatitis B. Whether this is related specifically to a non-A, non-B hepatitis agent requires identification of the viral agents that cause non-A, non-B hepatitis.</description><subject>Adult</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - microbiology</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Viral - analysis</subject><subject>Hepatitis B - diagnosis</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis, Chronic - complications</subject><subject>Hepatitis, Chronic - microbiology</subject><subject>Humans</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - microbiology</subject><subject>Male</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNpFUMtOwzAQtBColMeFO5JPHJACdh62c2wLpUgVcACukeOsW1dJHOyEir8nUSo47Wh2ZrQ7CF1RckcJ4ffzJaFhyhinR2hKEx4FYcLEMZoSynpMKTtFZ97vCCEpp2yCJqEIGUnDKdq9OVNJ94O30MjWKijLrpQOK-mUqW0lsbZlafem3uDa1r4BZbRRAw7mo8m0xuO9abe47Srr8MPLDNew6Rff0LsdXs0_B_ICnWhZerg8zHP0sXx8X6yC9evT82K2DlR_VRvEES0EIUkBRcQ1U0BzJZQqINc6zxMeF0ATIXXIRBynVCggAFL1nBBRmrPoHN2MuY2zXx34NquMHx6TNdjOZ5wLzmmS9MLbUaic9d6BzpqxjIySbCg2-y-2F18fUru8guJPemgy-gUbU3QF</recordid><startdate>198712</startdate><enddate>198712</enddate><creator>Cohen, E B</creator><creator>Gang, D L</creator><creator>Zeldis, J B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198712</creationdate><title>Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA</title><author>Cohen, E B ; Gang, D L ; Zeldis, J B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-431d8005ded37f6ce1bc8ccdebffbb574de158af26844918ce0eeac1588839b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - microbiology</topic><topic>DNA, Neoplasm - analysis</topic><topic>DNA, Viral - analysis</topic><topic>Hepatitis B - diagnosis</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis, Chronic - complications</topic><topic>Hepatitis, Chronic - microbiology</topic><topic>Humans</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - microbiology</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, E B</creatorcontrib><creatorcontrib>Gang, D L</creatorcontrib><creatorcontrib>Zeldis, J B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, E B</au><au>Gang, D L</au><au>Zeldis, J B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1987-12</date><risdate>1987</risdate><volume>32</volume><issue>12</issue><spage>1428</spage><epage>1430</epage><pages>1428-1430</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>An association between non-A, non-B hepatitis and hepatocellular carcinoma has been made on the basis of negative serological markers for hepatitis B virus (HBV); however, hepatocellular carcinomas have been found to contain hepatitis B virus deoxyribonucleic acid (HBV DNA) in individuals who lack serological markers of HBV infection. 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source | Springer Online Journal Archives |
subjects | Adult Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - microbiology DNA, Neoplasm - analysis DNA, Viral - analysis Hepatitis B - diagnosis Hepatitis B virus - genetics Hepatitis, Chronic - complications Hepatitis, Chronic - microbiology Humans Liver Neoplasms - etiology Liver Neoplasms - microbiology Male |
title | Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA |
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