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Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA

An association between non-A, non-B hepatitis and hepatocellular carcinoma has been made on the basis of negative serological markers for hepatitis B virus (HBV); however, hepatocellular carcinomas have been found to contain hepatitis B virus deoxyribonucleic acid (HBV DNA) in individuals who lack s...

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Published in:Digestive diseases and sciences 1987-12, Vol.32 (12), p.1428-1430
Main Authors: Cohen, E B, Gang, D L, Zeldis, J B
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creator Cohen, E B
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Zeldis, J B
description An association between non-A, non-B hepatitis and hepatocellular carcinoma has been made on the basis of negative serological markers for hepatitis B virus (HBV); however, hepatocellular carcinomas have been found to contain hepatitis B virus deoxyribonucleic acid (HBV DNA) in individuals who lack serological markers of HBV infection. Therefore, reports which ascribed a hepatocellular carcinoma to non-A, non-B hepatitis but did not examine the tumor for HBV DNA are open to question. We describe a case of chronic active hepatitis with primary hepatocellular carcinoma that lacked HBV DNA in the tumor, the nontumorous liver tissue, and serum. The individual lacked all serological markers for HBV infection. This report more fairly supports the association between hepatocellular carcinoma and chronic hepatitis not due to hepatitis B. Whether this is related specifically to a non-A, non-B hepatitis agent requires identification of the viral agents that cause non-A, non-B hepatitis.
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subjects Adult
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - microbiology
DNA, Neoplasm - analysis
DNA, Viral - analysis
Hepatitis B - diagnosis
Hepatitis B virus - genetics
Hepatitis, Chronic - complications
Hepatitis, Chronic - microbiology
Humans
Liver Neoplasms - etiology
Liver Neoplasms - microbiology
Male
title Primary hepatocellular carcinoma following nonspecific non-B hepatitis with tumor DNA negative for HBV DNA
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