Novel Antiplatelet Naphthalene from Rhamnus nakaharai

A new naphthalene derivative, isotorachrysone [1], was isolated from the stem bark of Rhamnus nakaharai along with several known compounds. The antiplatelet effects of isotorachrysone [1], isotorachrysone peracetate [2], 6-methoxysorigenin [3], quercetin 3-O-methyl ether [4], and quercetin 3-O-methy...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1995-12, Vol.58 (12), p.1934-1940
Main Authors: Lin, Chun-Nan, Lu, Chai-Ming, Lin, Hsien-Cheng, Ko, Feng-Nien, Teng, Che-Ming
Format: Article
Language:English
Subjects:
Animals
BARK
Biological and medical sciences
CHEMICAL COMPOSITION
Collagen - pharmacology
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CORTEZA
DERIVATIVES
DESINFECTANT
DESINFECTANTES
DISINFECTANTS
DRUG PLANTS
ECORCE
ESPECTROMETRIA
General pharmacology
In Vitro Techniques
INDUMENTARIA DE PROTECCION
INHIBICION
INHIBITION
ISOTORACHRYSONE
Magnetic Resonance Spectroscopy
Medical sciences
MOLECULAR CONFORMATION
MOLECULAR STRUCTURE
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Stems - chemistry
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - isolation & purification
Platelet Aggregation Inhibitors - pharmacology
Platelet Count - drug effects
PLATELETS
PROTECTIVE CLOTHING
Rabbits
RHAMNUS
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STEMS
TAIWAN
TALLO
THROMBOCYTE
TIGE
TROMBOCITOS
VETEMENT DE PROTECTION
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Description
Summary:A new naphthalene derivative, isotorachrysone [1], was isolated from the stem bark of Rhamnus nakaharai along with several known compounds. The antiplatelet effects of isotorachrysone [1], isotorachrysone peracetate [2], 6-methoxysorigenin [3], quercetin 3-O-methyl ether [4], and quercetin 3-O-methyl ether peracetate [5] were studied using washed rabbit platelets. Of the compounds tested, 1, 2, 4, and 5 showed potent antiplatelet effects on arachidonic acid (AA-) and collagen-induced platelet aggregation. Compound 5 also showed potent antiplatelet effects on platelet-activating factor-(PAF-) induced platelet aggregation. Isotorachrysone [1] and its peracetate [2] were also studied for antiplatelet activity in human platelet-rich plasma (PRP) and both showed potent inhibition of the secondary aggregation induced by epinephrine. The antiplatelet effects of 1 and 2 are due partially to an inhibitory effect on thromboxane formation.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50126a023