Evidence for the elaboration of multiple axons by developing dentate granule cells

A sample of 185 Neurobiotin-filled dentate granule cells has been collected from rats aged P14 to P120 in a study of the effects of serotonin (5-hydroxytryptamine, 5-HT) depletion on granule cell development. A small number (5.9%) of these neurons exhibit more than one axon. These neurons have morph...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Developmental brain research 1995-12, Vol.90 (1), p.194-197
Main Authors: Yan, Wei, Young, Jeffrey L., Haring, John H.
Format: Article
Language:English
Subjects:
Animals
Axon
Axons - ultrastructure
Dentate Gyrus - growth & development
Dentate Gyrus - ultrastructure
Fascia dentata
Granule cell
Hippocampal formation
Interneurons - ultrastructure
Intracellular filling
Male
Neurobiotin
Neuron development
Neurons - ultrastructure
Phenotype
Rats
Rats, Sprague-Dawley
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A sample of 185 Neurobiotin-filled dentate granule cells has been collected from rats aged P14 to P120 in a study of the effects of serotonin (5-hydroxytryptamine, 5-HT) depletion on granule cell development. A small number (5.9%) of these neurons exhibit more than one axon. These neurons have morphologies consistent with that described for dentate granule cells. One axon typically arises from the soma while additional axons take origin from either dendrites or the soma. Both axons may be mossy fibers or one axon may be a mossy fiber and the second assume a morphology and distribution similar to that described for interneurons. These latter neurons therefore exhibit a mixed phenotype by having a granule cell morphology and an interneuronal axon type. These data suggest that some granule cells give rise to multiple mossy fibers or express a mixed axonal phenotype during maturation.
ISSN:0165-3806
DOI:10.1016/0165-3806(96)83502-4