Dental anxiety and the absorption of orally administered erythromycin stearate

Erythromycin stearate is an acid labile antibiotic, therefore fear and apprehension, which are known to affect gastric motility, may produce erratic absorption resulting in lower serum levels. The mean (SD) serum erythromycin concentration 75 minutes after a 1.5 gm oral dose of erythromycin stearate...

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Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1995-12, Vol.80 (6), p.660-665
Main Authors: Coulter, Wilson A., McGimpsey, John G., Coffey, Alan, Strawbridge, Joanne, Linden, Gerard J.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic Prophylaxis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological Availability
Dental Anxiety - physiopathology
Dental Care for Chronically Ill - psychology
Dental Prophylaxis - psychology
Dentistry
Endocarditis, Bacterial - prevention & control
Erythromycin - analogs & derivatives
Erythromycin - blood
Erythromycin - pharmacokinetics
Erythromycin - therapeutic use
Female
Gastric Emptying - physiology
Humans
Intestinal Absorption - physiology
Male
Manifest Anxiety Scale
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Regression Analysis
Statistics, Nonparametric
Surveys and Questionnaires
Tooth Extraction - psychology
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Summary:Erythromycin stearate is an acid labile antibiotic, therefore fear and apprehension, which are known to affect gastric motility, may produce erratic absorption resulting in lower serum levels. The mean (SD) serum erythromycin concentration 75 minutes after a 1.5 gm oral dose of erythromycin stearate to 45 patients was 8.7 (4.8) mg/L and ranged widely from 0.4 to 20.5 mg/L. The serum concentration of erythromycin was below therapeutic levels (1.0 mg/L) in two patients. No significant association was found between anxiety and serum levels of erythromycin when age, gender, and gastric distress were taken into account. It is concluded that dental anxiety may indirectly influence the uptake of oral erythromycin stearate; but this relationship is complex, and there is no evidence from this study that increased dental anxiety decreases the uptake of the drug.
ISSN:1079-2104
1528-395X
DOI:10.1016/S1079-2104(05)80247-1