HLA class II analysis in Jewish Israeli narcoleptic patients

HLA class II was investigated in eight Jewish narcoleptic patients, representing the total of such patients known in Israel at present, and in three patients suffering from sleep disturbances other than narcolepsy. All (11 out of 11) patients carried the serologic specificities DR2, DQ6 (DQ1). At th...

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Bibliographic Details
Published in:Human immunology 1995-12, Vol.44 (4), p.199-202
Main Authors: Kwon, Oh J., Peled, Nir, Miller, Keren, Pillar, Guiora, Peled, Ron, Lavie, Peretz, Brautbar, Chaim, Amar, Avraham
Format: Article
Language:English
Subjects:
Alleles
Case-Control Studies
Disorders of Excessive Somnolence - genetics
Disorders of Excessive Somnolence - immunology
Gene Frequency
Genetic Linkage
HLA-D Antigens - genetics
HLA-DQ Antigens - genetics
HLA-DR2 Antigen - genetics
Humans
Israel
Jews - genetics
Narcolepsy - diagnosis
Narcolepsy - genetics
Narcolepsy - immunology
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Summary:HLA class II was investigated in eight Jewish narcoleptic patients, representing the total of such patients known in Israel at present, and in three patients suffering from sleep disturbances other than narcolepsy. All (11 out of 11) patients carried the serologic specificities DR2, DQ6 (DQ1). At the DNA level, all narcoleptics were found to be DRB 1 ∗1501, DQA1 ∗0102, DQB 1 ∗0602 which indicates that the susceptibility gene may be located within the HLA class II region, DR, and/or DQ. As for the nonnarcoleptic patients with idiopathic hypersomnia, they carried different alleles of DR2 and DQ6, namely DRB 1 ∗1502, DQA1 ∗0103, DQB1 ∗0601. This study confirms that the incidence of narcolepsy in Israel is extremely low and that HLA class II genes or a gene(s) tightly linked to them are involved in the disease.
ISSN:0198-8859
1879-1166
DOI:10.1016/0198-8859(95)00106-9