INFLUENCE OF PYRIDOXAL 5′-PHOSPHATE ON ETHANOL-INDUCED CHANGES IN HISTAMINE CATABOLISM IN THE GUINEA PIG

In guinea pigs, chronic intragastric administration of a 20% ethanol solution for 18 days (in increasing doses from 5 to 10 g/kg/day) leads, on the 18th day, to an enhancement of histamine level in the liver and the small intestine by up to 170% and 180% respectively. In these tissues the rate of hi...

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Bibliographic Details
Published in:Alcohol and alcoholism (Oxford) 1987, Vol.22 (4), p.389-394
Main Authors: KIERSKA, DANUTA, SASIAK, KRYSTYNA, MASLINSKI, CZESLAW
Format: Article
Language:English
Subjects:
Animals
Ethanol - pharmacology
Female
Guinea Pigs
Histamine - metabolism
Histamine N-Methyltransferase - metabolism
Intestine, Small - drug effects
Intestine, Small - metabolism
Liver - drug effects
Liver - metabolism
Male
Oxidation-Reduction
Pyridoxal Phosphate - pharmacology
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Summary:In guinea pigs, chronic intragastric administration of a 20% ethanol solution for 18 days (in increasing doses from 5 to 10 g/kg/day) leads, on the 18th day, to an enhancement of histamine level in the liver and the small intestine by up to 170% and 180% respectively. In these tissues the rate of histamine oxidative catabolism was depressed by about 20%. Histamine N-methyltransferase activity, as well as the level of acetylhistamine were not affected. Pyridoxal 5′-phosphate (2 mg/animal/day) tended to normalize both histamine levels and the rate of histamine oxidative catabolism.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/oxfordjournals.alcalc.a044727