Chemical Constituents of Halophilic Facultatively Anaerobic Bacteria, 1

Two new nitrotyramine derivatives, 1 and 2, along with five known aromatic compounds, were isolated from the culture broth of a facultatively anaerobic, halophilic bacterium isolated from a sediment from the Great Salt Plains, Alfalfa County, Oklahoma. The structures of the new compounds were determ...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1995-12, Vol.58 (12), p.1950-1954
Main Authors: Fu, Xiong, Schmitz, Francis J, Tanner, Ralph S
Format: Article
Language:English
Subjects:
AMINAS
AMINE
AMINES
ANAEROBES
ANAEROBIOSE
ANAEROBIOSIS
Animals
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Applied microbiology
AROMATIC COMPOUNDS
BACTERIA
Bacteria, Anaerobic - chemistry
Biological and medical sciences
CELL CULTURE
CELL LINES
CHEMICAL COMPOSITION
Chemotherapic agents
COMPOSE AROMATIQUE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
COMPUESTOS AROMATICOS
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXIC COMPOUNDS
DERIVATIVES
ESPECTROMETRIA
FILTRACION
FILTRATION
FLORA DEL SUELO
FLORE DU SOL
Fundamental and applied biological sciences. Psychology
LEUCEMIA
LEUCEMIE
LEUKAEMIA
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Mice
Microbiology
MICROORGANISME
MICROORGANISMOS
MICROORGANISMS
MOLECULAR CONFORMATION
molecular structure
murine leukemia p-388 cell line
OKLAHOMA
SALT TOLERANCE
SEDIMENT
SEDIMENTO
SOIL FLORA
Soil Microbiology
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOLERANCE AU SEL
TOLERANCIA A LA SAL
TOXIC SUBSTANCES
TYRAMINE
Tyramine - analogs & derivatives
Tyramine - chemistry
Tyramine - isolation & purification
Tyramine - pharmacology
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Summary:Two new nitrotyramine derivatives, 1 and 2, along with five known aromatic compounds, were isolated from the culture broth of a facultatively anaerobic, halophilic bacterium isolated from a sediment from the Great Salt Plains, Alfalfa County, Oklahoma. The structures of the new compounds were determined from spectral data and were confirmed by synthesis from tyramine hydrochloride. Compound 1 showed cytotoxicity against the murine leukemia P-388 cell line (IC50 3 micrograms/ml).
ISSN:0163-3864
1520-6025
DOI:10.1021/np50126a026