Transcription of the Y chromosomal gene, Sry, in adult mouse brain

The Y chromosomal gene Sry encodes a putative transcription factor which appears to serve as a master switch initiating testicular development. Here we show that this gene is transcribed in hypothalamus, midbrain, and testis of adult male but not adult female mice. In contrast to its circular transc...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 1995-10, Vol.33 (1), p.179-182
Main Authors: Lahr, Georgia, Maxson, Stephen C., Mayer, Anette, Just, Walter, Pilgrim, Christof, Reisert, Ingrid
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Female
Genetic Code
Hypothalamus
Hypothalamus - metabolism
Male
Mammal
Mesencephalon - metabolism
Mice
Mice, Inbred Strains
Midbrain
Molecular Sequence Data
Sexual dimorphism
Sexual Maturation
Sry
Testis - metabolism
Transcription, Genetic
Y Chromosome
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Summary:The Y chromosomal gene Sry encodes a putative transcription factor which appears to serve as a master switch initiating testicular development. Here we show that this gene is transcribed in hypothalamus, midbrain, and testis of adult male but not adult female mice. In contrast to its circular transcripts in adult testis, those in brain are linear and may be translated. We propose that Sry exerts a role in the regulation of sex differentiation of the mammalian nervous system.
ISSN:0169-328X
1872-6941
DOI:10.1016/0169-328X(95)00136-G