Simple high-performance liquid chromatographic analysis of phenol and p-cresol in urine and feces

Previous reports which present methods of analysis of phenol and p-cresol by HPLC are usually designed for the detection of these compounds in urine, can be complicated by the use of uncommon equipment or additional techniques such as steam distillation or derivatisation, or concentrate on the detec...

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Bibliographic Details
Published in:Journal of chromatography. B, Biomedical applications Biomedical applications, 1995-12, Vol.674 (2), p.187-191
Main Authors: Birkett, A.M., Jones, G.P., Muir, J.G.
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid - methods
Chromatography, High Pressure Liquid - statistics & numerical data
Cresols - analysis
Cresols - urine
Feces - chemistry
Humans
p-cresol
Phenol
Phenols - analysis
Phenols - urine
Reference Values
Spectrophotometry, Ultraviolet
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Summary:Previous reports which present methods of analysis of phenol and p-cresol by HPLC are usually designed for the detection of these compounds in urine, can be complicated by the use of uncommon equipment or additional techniques such as steam distillation or derivatisation, or concentrate on the detection of phenol rather than p-cresol. In this paper we report a simple method suitable for the analysis of phenol and p-cresol in both urine and feces, based upon extraction into ether following acid hydrolysis and UV detection.
ISSN:0378-4347
1572-6495
DOI:10.1016/0378-4347(95)00324-X