Resistance to Cryptococcus neoformans is associated with an inflammatory response to Toxoplasma gondii in the central nervous system of mice

We have studied the resistance of Toxoplasma gondii-infected mice to subsequent infection with Cryptococcus neoformans. Mice infected with the moderately virulent ME49 strain of T. gondii are resistant to proliferation of yeast cells in their brains after intravenous inoculation of the serotype A C....

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Bibliographic Details
Published in:Infection and Immunity 1996-01, Vol.64 (1), p.77-82
Main Authors: Aguirre, K.M. (Trudeau Institute, Saranac Lake, NY.), Sayles, P.C, Gibson, G.W, Johnson, L.L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Brain - radiation effects
Cryptococcosis - immunology
CRYPTOCOCCUS (CHAMPIGNON)
CRYPTOCOCCUS (HONGO)
Cryptococcus neoformans
Experimental mycoses and models
Gamma Rays
Infectious diseases
Lung - immunology
Male
Medical sciences
Meningoencephalitis - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, SCID
Mycoses
RATON
RESISTANCE AUX MALADIES
RESISTENCIA A LA ENFERMEDAD
SOURIS
Species Specificity
TOXOPLASMA GONDII
Toxoplasmosis, Animal - immunology
Whole-Body Irradiation
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Summary:We have studied the resistance of Toxoplasma gondii-infected mice to subsequent infection with Cryptococcus neoformans. Mice infected with the moderately virulent ME49 strain of T. gondii are resistant to proliferation of yeast cells in their brains after intravenous inoculation of the serotype A C. neoformans strain 184. The resistance serves to limit proliferation of yeast cells that colonize the brain. Maximal levels of resistance correlate not with maximal systemic specific anti-Toxoplasma resistance but rather with high levels of inflammatory response, presumably to parasites released from cysts in the brain. Resistance is localized, as mice infected with ME49 show only limited resistance in their lungs after intratracheal instillation of yeast cells, but there is substantial protection against development of cerebral cryptococcosis
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.64.1.77-82.1996