Intrauterine light delivery for photodynamic therapy of the human endometrium

Photodynamic therapy is currently being evaluated as a minimally invasive procedure for endometrial ablation not requiring anaesthesia. Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1995-11, Vol.10 (11), p.3067-3072
Main Authors: Fehr, M.K., Madsen, S.J., Svaasand, L.O., Tromberg, B.J., Eusebio, J., Berns, M.W., Tadir, Y.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
endometrium
Endometrium - drug effects
Endometrium - radiation effects
Equipment Design
Evaluation Studies as Topic
Female
Fiber Optic Technology - instrumentation
Genital system. Mammary gland
Humans
intrauterine light delivery
Light
light dosimetry
Medical sciences
Menopause
Middle Aged
Photochemotherapy - instrumentation
Photochemotherapy - methods
photodynamic therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
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Summary:Photodynamic therapy is currently being evaluated as a minimally invasive procedure for endometrial ablation not requiring anaesthesia. Light penetration depths at 630, 660 and 690 nm and the optimal configuration of intrauterine light-diffusing fibres were determined in 14 human uteri to assist in the design of a light intrauterine device. Post-menopausal ex-vivo uteri showed a significantly lower light penetration depth than pre-menopausal uteri. With a single central diffusing fibre inserted, the fluence rate measured in the uterine wall at the most remote point of the cavity decreased to 1.1 ± 0.4% of that measured at closest proximity, whereas it decreased to only 40.0 ± 9.0% with three fibres. Distension of the uterine cavity with 2 ml of an optically clear fluid increased the fluence rate at the fundus between the fibres at a depth of 2 mm by a factor of 4. We conclude that in normal-sized pre-menopausal uterine cavities, three diffusing fibres will deliver an optical dose above the photodynamic threshold level at a depth of 4 mm, even in the most remote areas, in
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a135851