Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas

The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to hu...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 1996-01, Vol.137 (1), p.375-378
Main Authors: Jhiang, S M, Sagartz, J E, Tong, Q, Parker-Thornburg, J, Capen, C C, Cho, J Y, Xing, S, Ledent, C
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Carcinoma, Papillary - genetics
Carcinoma, Papillary - pathology
Drosophila Proteins
Gene Dosage
Gene Expression
Mice
Oncogenes
Papillary thyroid carcinoma
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases - genetics
Ret protein
Thyroid
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Transgenic mice
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Summary:The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.
ISSN:0013-7227
1945-7170
DOI:10.1210/en.137.1.375