Cardiac ultrastructural effects of the platelet-activating factor and its antagonist BN 52021

Platelet-activating factor-induced ultrastructural changes of myocardium were examined in isolated perfused guineapig heart. The platelet-activating factor (10 -9-10 +7 M) caused the following electron microscopic changes: a) dilated capillaries filled with platelets and aggregated platelets. The en...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1995-12, Vol.47 (6), p.463-470
Main Authors: Kecskeméti, V., Balogh, I.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
BN 52021, antagonist of platelet activating factor
Cardiac effects, platelet activating factor Platelet activating factor antagonist
Cardiac ultrastructure
Cardiology. Vascular system
Coronary heart disease
Diterpenes
Female
Fibrinolytic Agents - pharmacology
Ginkgolides
Guinea Pigs
Heart
Heart - drug effects
Heart, platelet activating factor
Lactones - pharmacology
Male
Medical sciences
Myocardium - ultrastructure
Platelet activating factor
Platelet Activating Factor - antagonists & inhibitors
Platelet Activating Factor - pharmacology
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Summary:Platelet-activating factor-induced ultrastructural changes of myocardium were examined in isolated perfused guineapig heart. The platelet-activating factor (10 -9-10 +7 M) caused the following electron microscopic changes: a) dilated capillaries filled with platelets and aggregated platelets. The endothelial cells adjoining the platelets remained uninjured but pericapillary oedema was observed. b) in the myocardium intracellular oedema, myofibrillar alterations, decrease of matrix density and rupture of crest in mitochondria can be seen. c) Ca 2+ deposits in the cytoplasm increased and appeared in mitochondria, too. d) the intramitochondrially localised cytochromoxydase and succinic dehydrogenase activities were decreased. e) using lanthanum tracer permeability alterations were observed. Pretreatment with BN 52021 (10 -6 M) completely prevented the morphological effects of the platelet-activating factor. From these results we conclude that the platelet-activating factor-induced vascular and ischemic like cellular damage appears to play an important role in the pathophysiology of myocardial ischemia.
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(11)80329-5