Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs

Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs admin...

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Bibliographic Details
Published in:Pharmacological research 1995-10, Vol.32 (4), p.177-187
Main Author: Benedetti, M. Strolin
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
AIDS
AIDS/HIV
enzyme induction
Humans
Isoniazid - pharmacology
rifabutin
Rifabutin - pharmacokinetics
rifampicin
tuberculosis
Tuberculosis - drug therapy
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Summary:Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs administered concomitantly to humans (isoniazid, ethambutol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been reviewed.
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(05)80021-0