Microbiological perspectives of co-trimoxazole

Trimethoprim-sulfamethoxazole in vitro activity was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against isolates of 24 gram-negative and 11 gram-positive species. The incidence of more than 10% of strains with minimal inhibitory concentrations above 32 mg/l was restricted to...

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Bibliographic Details
Published in:Infection 1987-09, Vol.15 Suppl 5 (S5), p.S232-S235
Main Authors: Bauernfeind, A, Hörl, G, Przyklenk, B
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Drug Combinations - pharmacology
Drug Resistance, Microbial
Escherichia coli - drug effects
Humans
Microbial Sensitivity Tests
Sulfamethoxazole - pharmacology
Trimethoprim - pharmacology
Trimethoprim, Sulfamethoxazole Drug Combination
Urinary Tract Infections - microbiology
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Summary:Trimethoprim-sulfamethoxazole in vitro activity was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against isolates of 24 gram-negative and 11 gram-positive species. The incidence of more than 10% of strains with minimal inhibitory concentrations above 32 mg/l was restricted to Escherichia coli, Shigella spp., Klebsiella pneumoniae, Providencia rettgeri, Morganella morganii, methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Occasionally, Streptococcus pneumoniae and Haemophilus influenzae strains with MICs above 32 mg/l were identified. Co-trimoxazole in vitro activity was superior to the comparative drugs for the majority of species. Co-trimoxazole remains an active combination against major pathogens of infections of the upper and lower respiratory, urinary tract and enteric infections with a still low incidence of resistant organisms.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01643195