Cytogenetical observations in five human anaplastic thyroid carcinomas

Mark, J., Ekedahl, C., Dahlenfors, K. and Westermark B. 1987. Cytogenetical observations in five human anaplastic thyroid carcinomas. —Hereditas 107 163–174. Lund, Sweden. ISSN 0018–0661. Received January 14, 1987 Observations by banding methods in 5 human anaplastic thyroid carcinomas are reported....

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Bibliographic Details
Published in:Hereditas 1987, Vol.107 (2), p.163-174
Main Authors: MARK, JOACHIM, EKEDAHL, CLAES, DAHLENFORS, RIGMOR, WESTER-MARK, BENGT
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma - genetics
Chromosome Aberrations
Endocrinopathies
Female
Humans
Karyotyping
Male
Malignant tumors
Medical sciences
Thyroid Neoplasms - genetics
Thyroid. Thyroid axis (diseases)
Translocation, Genetic
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Summary:Mark, J., Ekedahl, C., Dahlenfors, K. and Westermark B. 1987. Cytogenetical observations in five human anaplastic thyroid carcinomas. —Hereditas 107 163–174. Lund, Sweden. ISSN 0018–0661. Received January 14, 1987 Observations by banding methods in 5 human anaplastic thyroid carcinomas are reported. All tumors had a polyploid, often very flat, mode. Karyotype analyses, however, revealed that in spite of a mostly profound numerical‐structural variability, all carcinomas were monoclonal products. Numerical deviations in common were proportional gains of No. 20 and often losses of Nos. 1,4and 13. Structural aberrations particularly common were a variety of Robertsonian translocations and isochromosomes. Double‐minutes (Dms) were seen in 2 tumors. The Dms in one of these cases did not contain any of the oncogenes previously demonstrated to be amplified in human tumors harbouring correspondent aberrations. The present study indicates that undifferentiated thyroid carcinomas are easily established as cell lines. Because of this characteristic and, also, the suggestive common occurrence of Dms, the anaplastic carcinomas seem to comprise an unusually favourable material for future molecular studies.
ISSN:0018-0661
1601-5223
DOI:10.1111/j.1601-5223.1987.tb00281.x