Comparative investigations on the actions of ACTH1-24, somatostatin, neurotensin, substance P and vasopressin on locus coeruleus neuronal activity in vitro

A considerable number of neuropeptides have been localized immunohistochemically in the area of the locus coeruleus of the rat. The objective of this study was to assess the actions of some of these transmitter candidates on spontaneously active locus coeruleus neurons in vitro. The effects of bath-...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology 1987-10, Vol.336 (4), p.434-437
Main Authors: OLPE, H.-R, STEINMANN, M. W, POZZA, M. F, HAAS, H. L
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin - pharmacology
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cosyntropin - pharmacology
Fundamental and applied biological sciences. Psychology
Gerbillinae
In Vitro Techniques
Locus Coeruleus - drug effects
Male
Neurons - drug effects
Neuropeptides - pharmacology
Neurotensin - pharmacology
Somatostatin - pharmacology
Substance P - pharmacology
Vasopressins - pharmacology
Vertebrates: nervous system and sense organs
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Summary:A considerable number of neuropeptides have been localized immunohistochemically in the area of the locus coeruleus of the rat. The objective of this study was to assess the actions of some of these transmitter candidates on spontaneously active locus coeruleus neurons in vitro. The effects of bath-applied peptides on the discharge rate of individual locus coeruleus neurons were investigated. A midpontine slice preparation of the gerbil brain was used. Excitatory dose-dependent effects were found with four peptides with the following rank order of potency: Substance P, (Arg8)-vasopressin, neurotensin, ACTH1-24. Somatostatin hyperpolarized all neurons tested. Given the pronounced effects seen with substance P, somatostatin and vasopressin in the nanomolar range, it is conceivable that these peptides may have a role in regulating neuronal activity in locus coeruleus.
ISSN:0028-1298
1432-1912
DOI:10.1007/bf00164879