Impaired induction of ornithine decarboxylase activity following nerve crush in the streptozotocin-diabetic rat

Ornithine decarboxylase activity was measured in the dorsal root ganglia from crushed and uncrushed contralateral sciatic nerve of control and streptozotocin-diabetic rats. A further group of diabetic rats was treated with insulin throughout the experiment. Ornithine decarboxylase activity in gangli...

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Bibliographic Details
Published in:Diabetologia 1987-12, Vol.30 (12), p.963-965
Main Authors: MCLEAN, W. G, CHAPMAN, J. E, CULLUM, N. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzyme Induction
Female
Medical sciences
Nerve Crush
Nerve Regeneration
Ornithine Decarboxylase - biosynthesis
Rats
Rats, Inbred Strains
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Summary:Ornithine decarboxylase activity was measured in the dorsal root ganglia from crushed and uncrushed contralateral sciatic nerve of control and streptozotocin-diabetic rats. A further group of diabetic rats was treated with insulin throughout the experiment. Ornithine decarboxylase activity in ganglia from uncrushed nerves was the same in diabetic and non-diabetic rats. A significant (greater than 4-fold) increase in mean levels of ornithine decarboxylase activity 72 h after crush injury was found in ganglia from crushed nerves in non-diabetic but not in diabetic rats. The enzyme activity in ganglia from diabetic rats treated with insulin resembled that in non-diabetic rats. Twenty-four hours after crush injury, ornithine decarboxylase activity in ganglia from crushed nerves was higher in non-diabetic than in diabetic animals. This may be responsible for the delayed and defective nerve regeneration known to occur in peripheral nerve of the streptozotocin-diabetic rat.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00295882